Our Research Goals
1
Characterize the initial presentation and course of clinical, neuroimaging, and fluid markers of participants diagnosed with CADASIL and to compare these diagnostic indications of disease with those from non-carriers
If markers diverge between CADASIL and non-carriers does it indicate a worsening condition?
Determine how the stages of disease severity should be assessed
2
Clarify genetic, health, and lifestyle factors that impact clinically meaningful genetic, health, and lifestyle outcomes in CADASIL through genetic tools, medical history, and lifestyle questionnaires.
Better understand how variant NOTCH3 mutations, risk-increasing behaviors, coexisting medical conditions, and Alzheimer’s disease markers influence the disease onset of CADASIL.
3
Develop a model for CADASIL which is also more broadly applicable to vascular cognitive impairment and dementia.